Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
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Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects

Nature Methods, Published online: 25 April 2024; doi:10.1038/s41592-024-02247-0ESI-cryoPrep is a cryo-EM specimen preparation method that employs electrospray ionization techniques to deposit charged macromolecule-containing droplets on EM grids. Demonstrated across various protein samples, this approach effectively prevents biomolecule adsorption at...

Thu Apr 25, 2024 16:32
Quantification of absolute labeling efficiency at the single-protein level

Nature Methods, Published online: 24 April 2024; doi:10.1038/s41592-024-02242-5Super-resolution imaging of reference and target structures enables precise determination of the labeling efficiency of high-affinity binding proteins in cells for improved quantitative assessment of protein organization at the single-molecule level.

Wed Apr 24, 2024 16:15
De novo identification of CD4<sup>+</sup> T cell epitopes

Nature Methods, Published online: 24 April 2024; doi:10.1038/s41592-024-02255-0SABR-IIs are engineered bifunctional receptors that enable CD4+ T cell antigen discovery.

Wed Apr 24, 2024 16:15
scRNA-seq: oh, the joys

Nature Methods, Published online: 23 April 2024; doi:10.1038/s41592-024-02263-0To those who seek transcriptomic information at high resolution, scale and throughput, single-cell RNA sequencing brings the data. Scientists share tips and future plans as they reflect on the method’s rise to stardom.

Tue Apr 23, 2024 19:59
Can AlphaFold’s breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?

Nature Methods, Published online: 23 April 2024; doi:10.1038/s41592-024-02240-7This Perspective discusses the potential of protein structure-prediction models for exploring the structural landscape and specificity of TCR–pMHC interactions.

Tue Apr 23, 2024 15:56
Simplifying deep learning to enhance accessibility of large-scale 3D brain imaging analysis

Nature Methods, Published online: 22 April 2024; doi:10.1038/s41592-024-02246-1We created DELiVR, a deep-learning pipeline for 3D brain-cell mapping that is trained with virtual reality-generated reference annotations. It can be deployed via the user-friendly interface of the open-source software Fiji, which makes the analysis of large-scale 3D brain...

Mon Apr 22, 2024 15:36

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