Excessive intragastric alcohol administration exacerbates hepatic encephalopathy (HE) and induces neuronal loss/injury marked by higher levels of 4-hydroxynonenal (4-HNE)-modified proteins and decreased total antioxidant capacity (TAC) in the cerebellum of bile duct ligated (BDL) rats. Abstract Hepatic encephalopathy (HE) is defined as decline...

Journal of Neuroscience Research, Volume 102, Issue 5, May 2024.

4R-cembranoid is a natural compound that protects neurons against LPS-induced neuroinflammation by reducing the number of pro-inflammatory microglia and by promoting the secretion of astrocytic neuroprotective factors in the mice hippocampus. Abstract Chronic neuroinflammation has been implicated in neurodegenerative disease pathogenesis. A key...

Altered endogenous VIP VPAC1 receptor modulation of hippocampal CA1 synaptic plasticity following mismatch novelty training. The study suggests that VIP receptor ligands may be useful to co-adjuvate cognitive stimuli therapies based on mismatch novelty, aiming at the cognitive rescue of aged individuals or epilepsy patients. Abstract Novelty...

Iron deficiency (ID), induced by divalent metal transporter 1 silencing or deferoxamine treatment, affects astrocyte (AST) maturation and mitochondrial dynamics. ID AST impair oligodendrocyte differentiation partly through reduced soluble factor expression. Abstract Iron deficiency (ID) has been shown to affect central nervous system (CNS) development...

In the synaptic connections between the retina and the SCN, aged mice displayed decreased postsynaptic responses following RHT stimulation, suggesting fewer fibers arriving from the retina. However, compensatory mechanisms were detected in these animals, such as short-term facilitation, synaptic quantum increase, and higher expression of synaptic...