We investigate the association between brain entropy (BEN) estimated from resting-state fMRI and pain intensity in a sample including young adults, middle-aged participants, and elders. Main results show that the interaction between age and pain intensity is related to BEN increase in pain-related brain regions. Further investigation showed that,...

Abstract The ubiquity of nanoparticles, sourced from both natural environments and human activities, presents critical challenges for public health. While offering significant potential for innovative biomedical applications—especially in enhancing drug transport across the blood–brain barrier—these particles also introduce possible hazards due to...

Astrocytes in the hypothalamus differentially metabolize palmitic acid and oleic acid, two fatty acids commonly found in our diets, with this possibly being involved in our differential overall metabolic response to these nutrients. Abstract Diets rich in saturated fats are more detrimental to health than those containing mono- or unsaturated...

Pharmacological IDO1 inhibition was administered following the fluid percussion injury model of traumatic brain injury in young adult male rats. IDO1 inhibition prevented the increase in kynurenine pathway activity that was seen in the brain of the vehicle-treated group at 3 days postinjury, as demonstrated by the ratio of kynurenine to tryptophan...

Excessive intragastric alcohol administration exacerbates hepatic encephalopathy (HE) and induces neuronal loss/injury marked by higher levels of 4-hydroxynonenal (4-HNE)-modified proteins and decreased total antioxidant capacity (TAC) in the cerebellum of bile duct ligated (BDL) rats. Abstract Hepatic encephalopathy (HE) is defined as decline...

Journal of Neuroscience Research, Volume 102, Issue 5, May 2024.