Wiley Online Library : The Journal of Clinical Pharmacology
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Exposure to Macrolides During Pregnancy and the Risk for Spontaneous Abortions: A Population‐Based Retrospective Cohort Study

Abstract Previous studies evaluating the risk of spontaneous abortions following exposure to macrolides reported controversial results. The goal of the current study was to examine the risk for spontaneous abortions following exposure to macrolides during pregnancy. We conducted a population-based retrospective cohort study by linking three computerized...

Wed May 29, 2024 12:02
Issue Information

The Journal of Clinical Pharmacology, Volume 64, Issue 6, Page 637-641, June 2024.

Tue May 28, 2024 11:58
Value of Assessing 1‐Hydroxymidazolam in Drug‐Drug Interaction Studies with Midazolam as a Substrate of Cytochrome P450 3A

Abstract The purpose of this overview was to perform an exploratory analysis of in-house drug-drug interaction (DDI) studies conducted with investigational drugs and oral midazolam to assess the value of measuring 1-OH-midazolam (1-OHM) in such studies. The perpetrator effect of the investigational drugs on cytochrome P450 3A (CYP3A) was assessed by...

Mon May 27, 2024 12:50
Assessing the Utility of a Genotype‐Guided Tacrolimus Equation in African American Kidney Transplant Recipients: A Single Institution Retrospective Study

Abstract Tacrolimus metabolism is heavily influenced by the CYP3A5 genotype, which varies widely among African Americans (AA). We aimed to assess the performance of a published genotype-informed tacrolimus dosing model in an independent set of adult AA kidney transplant (KTx) recipients. CYP3A5 genotypes were obtained for all AA KTx recipients (n =...

Tue May 21, 2024 12:32
Exposure–Response Analyses for Belzutifan to Inform Dosing Considerations and Labeling

Abstract Belzutifan (Welireg, Merck & Co., Inc., Rahway, NJ, USA) is an oral, potent hypoxia-inducible factor-2α inhibitor, recently approved in the United States for the treatment of von Hippel–Lindau (VHL) disease-associated renal cell carcinoma (RCC) and other VHL disease-associated neoplasms. Safety and efficacy were investigated in two clinical...

Fri May 17, 2024 11:36
Back Pedaling on Baclofen: Highlighting Concerns Surrounding Baclofen use in Phenibut Withdrawal

The Journal of Clinical Pharmacology, EarlyView.

Fri May 17, 2024 11:36

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