Nature Reviews Genetics, Published online: 08 May 2024; doi:10.1038/s41576-024-00741-xLogsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative analyses of the variation in tandemly repeating α-satellite DNA.

Nature Reviews Genetics, Published online: 07 May 2024; doi:10.1038/s41576-024-00736-8In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.

Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00737-7In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency and can be designed using a computational tool he created and named PEGG.

Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00735-9Renée Beekman discusses the possibilities for research into transient enhancers by highlighting a recent paper by Vermunt et al. that identifies how they can modulate gene silencing dynamics.

Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00734-wIn this Journal Club, Kirstyn Brunker highlights two papers published in 2017 that showcase how the emergence of portable sequencing capabilities improved the real-time response to infectious disease outbreaks on a global scale.

Nature Reviews Genetics, Published online: 24 April 2024; doi:10.1038/s41576-024-00720-2Targeted genome modification using CRISPR–Cas genome editing, base editing or prime editing is driving base research in plants and precise molecular breeding. The authors review the technological principles underlying these methods, approaches for their delivery...