Nature Immunology, Published online: 14 May 2024; doi:10.1038/s41590-024-01853-6How aging, immunity and cancer are related is incompletely understood. Data now show altered differentiation and loss of function of tumor-infiltrating T cells with aging. So-called TTAD cells seem to be involved.

Nature Immunology, Published online: 14 May 2024; doi:10.1038/s41590-024-01828-7Cancer and aging are associated with each other, but underlying mechanisms contributing to this correlation are unclear. Here the authors identify a dysfunctional T cell state that is distinct from typical T cell exhaustion and only occurs in the tumor microenvironment during...

Nature Immunology, Published online: 08 May 2024; doi:10.1038/s41590-024-01832-xOur work identifies previously unrecognized functional heterogeneity in tissue-resident interstitial macrophages. We have identified ten macrophage subsets, each thought to specifically contribute to recruiting and organizing cell types within tissues. Moreover, our findings...

Nature Immunology, Published online: 02 May 2024; doi:10.1038/s41590-024-01815-yIn this Review, the authors analyze evidence for autoimmunity against components of antimicrobial immunity, metaphorically represented by the mythical ouroboros snake eating its own tail.

Nature Immunology, Published online: 02 May 2024; doi:10.1038/s41590-024-01839-4Inflammatory fibroblasts remodeling in colitis

Nature Immunology, Published online: 02 May 2024; doi:10.1038/s41590-024-01840-xKeeping neonatal intestines happy