Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00735-9Renée Beekman discusses the possibilities for research into transient enhancers by highlighting a recent paper by Vermunt et al. that identifies how they can modulate gene silencing dynamics.

Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00734-wIn this Journal Club, Kirstyn Brunker highlights two papers published in 2017 that showcase how the emergence of portable sequencing capabilities improved the real-time response to infectious disease outbreaks on a global scale.

Nature Reviews Genetics, Published online: 29 April 2024; doi:10.1038/s41576-024-00737-7In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency and can be designed using a computational tool he created and named PEGG.

Nature Reviews Genetics, Published online: 24 April 2024; doi:10.1038/s41576-024-00720-2Targeted genome modification using CRISPR–Cas genome editing, base editing or prime editing is driving base research in plants and precise molecular breeding. The authors review the technological principles underlying these methods, approaches for their delivery...

Nature Reviews Genetics, Published online: 24 April 2024; doi:10.1038/s41576-024-00733-xIn this Journal Club article, Olivia Rissland describes how a 1987 paper by Don Cleveland and colleagues provided insight into co-translational gene regulation of tubulin.

Nature Reviews Genetics, Published online: 22 April 2024; doi:10.1038/s41576-024-00718-wIn this Review, Li and Durbin discuss how to generate telomere-to-telomere assemblies for large haploid or diploid genomes using currently available data types and algorithms, and outline remaining challenges in resolving highly repetitive sequences and polyploid...