Recently, the Biden-Harris administration proposed a 5-year program to eliminate HCV infection as a public health problem in the United States.[1] This HCV Elimination Program, housed within the Office of the Assistant Secretary of Health and led by former US National Institutes of Health Director Francis Collins, aims to expand screening, treatment,...

AbstractBackgroundPrimary antifungal prophylaxis with mold-active azoles is used to prevent invasive fungal infections in patients with high-risk hematological disorders; however, breakthrough infections occur, and the reasons for treatment failure are still not fully understood. To help inform clinical decisions, we sought to define microbiological,...

AbstractBackgroundLimited data exists on effects of intrapartum azithromycin on prevalence of carriage and antibiotic resistance of Enterobacterales.MethodsWe conducted a randomized trial in Gambia and Burkina Faso where women received intrapartum azithromycin (2g) or placebo. We determined impact of treatment on prevalence of carriage and antibiotic...

AbstractBackgroundPeople with HIV (PHIV) admitted to hospital have high mortality, with tuberculosis (TB) being the major cause of death. Systematic use of new TB diagnostics could improve TB diagnosis and might improve outcomes.MethodsWe conducted a cluster randomised trial among adult PHIV admitted to Zomba Central Hospital, Malawi. Admission-days...

AbstractBackgroundFew data are available on the real-world efficacy of receiving tenofovir-lamivudine-dolutegravir (DTG) as HIV treatment, particularly among young people in West Africa. Here, we evaluated pharmaco-virological outcomes and resistance profiles among Togolese children and adolescents.MethodsA cross-sectional study was conducted in Lomé,...