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Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP00012A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kyra R. Dvorak, Jetze J. Tepe This review highlights advances in isolation and synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties. Natural products...

Fri Apr 26, 2024 13:58
Medium-sized peptides from microbial sources with potential for antibacterial drug development

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP00002A, Review ArticleJianwei Chen, Wei Wang, Xubin Hu, Yujie Yue, Xingyue Lu, Chenjie Wang, Bin Wei, Huawei Zhang, Hong Wang This review summarizes the medium-sized antimicrobial peptides discovered in the last three decades (1993 to the end of 2022) and highlights the novel antibacterial mechanisms...

Tue Apr 23, 2024 13:20
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00068K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Herma C. Pierre, Chiraz Soumia M. Amrine, Michael G. Doyle, Amrita Salvi, Huzefa A. Raja, Jonathan R. Chekan, Andrew C. Huntsman, James R. Fuchs, Kebin Liu, Joanna...

Wed Apr 17, 2024 16:21
Hot off the Press

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP90015D, Hot off the Press ArticleRobert A. Hill, Andrew Sutherland A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as eugeniinaline A from Leuconotis eugeniifolia. To cite this article...

Mon Apr 15, 2024 12:16
Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00060E, Review ArticleSaket R. Bagde, Chu-Young Kim Structures of intact polyketide synthase modules reveal conformational rearrangements and suggest asynchronous use of reaction chambers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of...

Tue Mar 19, 2024 11:06
Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00064H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stephanie C. Heard, Jaclyn M. Winter This review highlights the utility of using adenylation domain structural data, biochemical assays, and computational predictions for prioritizing...

Fri Mar 15, 2024 14:28

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