The use of tFNAs as carriers to assemble the T-miR-149 complex reduced the expression of Pi3k and Akt involved in tumorigenesis and alterations in proteins related to cell apoptosis. The bionic drug delivery system has an effective tumour suppressive effect on OSCC in mice, revealing its potential clinical value in the treatment of OSCC. Abstract...

Tgm2 regulates BMP signalling activation to mediate hepatocyte metaplasia, thereby restoring liver injury. The Tgm2-BMP signalling axis plays a key role in the structure and function of BECs during ductular reaction. Abstract Transglutaminase 2 (Tgm2) plays an essential role in hepatic repair following prolonged toxic injury. During cholestatic...

Major ZGA occurs at the late-2 cell stage and involves the activation of thousands of genes, supporting early embryonic development. GATAD2B is one of the core subunits of the nucleosome remodelling and histone deacetylation (NuRD) complex. Our results demonstrate that GATAD2B is essential for pre-implantation embryonic development, in part through...

This research uncovers a novel phosphorylation-regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome-involved biomedical events. Abstract The biogenesis of exosomes that...

Illustration of the preparation of tFNAs-DJ-1 saRNAs complex and its anti-oxidative effects on human umbilical vein endothelial cells (HUVECs) and ARPE-19. Abstract Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the world's leading causes of blindness. The retinal pigment epithelium (RPE) and vascular endothelial cell...

This review summarises the novel roles of ferroptosis, pyroptosis, and necroptosis in anti-PD-1/PD-L1 immunotherapy. Targeting non-apoptotic regulated cell death in combination with anti-PD1/PD-L1 therapies holds promise as a prospective immunotherapy strategy for tumour treatment. Abstract Chemotherapy, radiotherapy, and immunotherapy represent...