What's new? While extrachromosomal circular DNA (eccDNA) has emerged as a key player in tumorigenesis, its contribution to breast cancer lymph node metastases remains elusive. This study shows the presence of distinct eccDNA profiles in primary breast cancers and their corresponding lymph node metastases, highlighting potential new biomarkers for...

International Journal of Cancer, EarlyView.

What's new? The influence of adiposity on colorectal cancer prognosis remains poorly characterised. Here, as part of CUP Global, the evidence on post-diagnosis adiposity and colorectal cancer outcomes was systematically synthesised using standardised criteria, and a non-linear dose–response meta-analysis was conducted for the first time. Reverse...

What's new? The roles of physical activity and sedentary behaviour in colorectal cancer prognosis are unclear. Here, as part of CUP Global, the authors performed a systematic review and meta-analysis on the associations of post-diagnosis physical activity and sedentary behaviour with all-cause and cause-specific mortality and recurrence among colorectal...

What's new? The role of diet in colorectal cancer prognosis is not well understood. As part of CUP Global, here the authors systematically reviewed, meta-analysed, and independently graded the quality of evidence on the associations of post-diagnosis dietary intake, dietary patterns, and supplement use with colorectal cancer prognosis. Whilst the...

What's new? A better understanding of the associations of post-diagnosis modifiable lifestyle factors with outcomes could inform tailored prevention strategies for colorectal cancer survivors. The Global Cancer Update Programme (CUP Global) conducted systematic reviews, meta-analyses, and independent quality of evidence grading on the associations...