What's new? Although mouse models are commonly used to assess the carcinogenic effects of environmental agents, challenges remain in the extrapolation of results to humans. In this study, a mathematical model of multistage carcinogenesis was employed to analyze existing radiation-related cancer mortality data from Japanese atomic bomb survivors and...

What's new? Salivary gland cancers (SGCs) are classified histologically into more than 20 types. This vast heterogeneity has slowed progress toward a standard treatment regimen for SGC. Here, the authors analyzed data from the Center for Cancer Genomics and Advanced Therapeutics database in Japan to better understand SGC characteristics and their...

International Journal of Cancer, EarlyView.

What's new Pembrolizumab monotherapy is approved for use as first-line palliative systemic treatment for head and neck squamous cell carcinoma (HNSCC). The approval of pembrolizumab was based on data from the KEYNOTE-048 trial, which enforced strict inclusion criteria. Here, the authors analyzed real-world data on first-line monotherapy with pembrolizumab...

What's New? Breast cancer survivors are at increased risk of second cancer. Whether differences in second cancer risk exist between racial and ethnic groups, however, remains uncertain. Here, data from Surveillance, Epidemiology, and End Results (SEER) registries was investigated to elucidate second cancer risk for Black, Latina, White, and Asian...

International Journal of Cancer, EarlyView.