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pubmed: cell cycle arrest

NCBI: db=pubmed; Term=cell cycle arrest
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Identification of 3-(9H-carbazol-9-yl)-2-(1,3-dioxoisoindolin-2-yl)propanoic acids as promising DNMT1 inhibitors

Eur J Med Chem. 2024 May 27;274:116538. doi: 10.1016/j.ejmech.2024.116538. Online ahead of print.ABSTRACTDNA methyltransferase 1 (DNMT1) is the primary enzyme responsible for maintaining DNA methylation patterns during cellular division, crucial for cancer development by suppressing tumor suppressor genes. In this study, we retained the phthalimide...

Sun Jun 2, 2024 07:52
Ginkgolic acids induce liver injury in mice through cell cycle arrest and immune stress under specific condition

Toxicon. 2024 May 30:107788. doi: 10.1016/j.toxicon.2024.107788. Online ahead of print.ABSTRACTGinkgo biloba L. is a valuable plant, which can be used for medicine, food and ornamental purposes. Despite the above benefits, the components of ginkgolic acids (GA) in ginkgo are considered to cause allergies, embryotoxicity, liver damage and some other...

Sun Jun 2, 2024 07:52
Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights

Bioorg Chem. 2024 May 19;149:107471. doi: 10.1016/j.bioorg.2024.107471. Online ahead of print.ABSTRACTApplying various drug design strategies including ring variation, substituents variation, and ring fusion, two series of 2-(alkylthio)-5-(arylidene/heteroarylidene)imidazolones and imidazo[1,2-a]thieno[2,3-d]pyrimidines were designed and prepared as...

Sun Jun 2, 2024 07:52
Qizhu Anticancer Prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes

J Ethnopharmacol. 2024 May 30:118400. doi: 10.1016/j.jep.2024.118400. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and this is largely attributed to the limitations of available therapeutic strategies. The traditional Chinese medicine Qizhu...

Sun Jun 2, 2024 07:52
METTL1-mediated tRNA m(7)G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade

J Exp Clin Cancer Res. 2024 May 31;43(1):154. doi: 10.1186/s13046-024-03076-x.ABSTRACTBACKGROUND: RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that tRNA modifications are related to various disease processes, including malignant tumors. However, the biological functions of methyltransferase-like...

Sun Jun 2, 2024 05:12
Crude extract of Ruellia tuberosa L. flower induces intracellular ROS, promotes DNA damage and apoptosis in Triple Negative Breast Cancer Cells

J Ethnopharmacol. 2024 May 29:118389. doi: 10.1016/j.jep.2024.118389. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Ruellia tuberosa L. (Acanthaceae) is a weed plant traditionally used in folklore medicine as a diuretic, anti-hypertensive, anti-pyretic, anti-cancerous, anti-diabetic, analgesic, and gastroprotective agent. It has been...

Sat Jun 1, 2024 18:29

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