pubmed: cell cycle arrest
Genome Integr. 2023 Sep 12;14:e20230002. doi: 10.14293/genint.14.1.003. eCollection 2023.ABSTRACTBreast cancer is the most common cause of malignancy and the second most common cause of death due to cancer in women. This heterogeneous disease is currently broadly classified as estrogen receptor (ER), progesterone receptor (PR) positive luminal tumors,...
ACS Omega. 2024 May 3;9(19):21416-21425. doi: 10.1021/acsomega.4c01752. eCollection 2024 May 14.ABSTRACTAs a critical mitotic regulator, Aurora kinase A (AURKA) is aberrantly activated in a wide range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of solid tumors. In this study, we evaluated the preclinical characteristics...
Anticancer Agents Med Chem. 2024 May 17. doi: 10.2174/0118715206304918240509111700. Online ahead of print.ABSTRACTBACKGROUND: Drug repurposing in oncology promises a high impact on many patients through its ability to provide access to novel, fast-tracked treatments. Previous studies have demonstrated that depression may influence tumor progression....
Cancer Cell Int. 2024 May 19;24(1):175. doi: 10.1186/s12935-024-03362-w.ABSTRACTBACKGROUND: The incidence and mortality of lung cancer is the highest in China and the world. Brain is the most common distant metastasis site of lung cancer. Its transfer mechanism and predictive biomarkers are still unclear. EZH2 participates in the catalysis of transcriptional...
Ecotoxicol Environ Saf. 2024 May 18;279:116461. doi: 10.1016/j.ecoenv.2024.116461. Online ahead of print.ABSTRACTPolystyrene nanoplastics (PS-NPs) have been reported to accumulate in the testes and constitute a new threat to reproductive health. However, the exact effects of PS-NPs exposure on testicular cells and the underlying mechanisms remain largely...
Bioorg Chem. 2024 May 15;148:107457. doi: 10.1016/j.bioorg.2024.107457. Online ahead of print.ABSTRACTBased on the significant biological activities and the remarkable physical and chemical properties of 1H-1,2,3-triazole pharmacophore, we herein adopted the strategy of click chemistry to combine the triazole fragment and the unique scaffold of 25-OCH3-PPD...