Abstract This work reports a new concept of cancer mask in situ to alter the specific biological functions of cancer cells. Metastatic cancer cells are highly invasive in part due to the presence of the glycan matrix in the cell membrane. Using a rational designed bio-orthogonal reaction, we reconstructed cancer cell surface in situ by incorporating...

Abstract In viral infections, natural killer (NK) cells exhibit anti-viral activity by inducing apoptosis in infected host cells and impeding viral replication through heightened cytokine release. Extracellular vesicles derived from NK cells (NK-EVs) also contain the membrane composition, homing capabilities, and cargo that enable anti-viral activity....

Abstract Proteolysis targeting chimeras (PROTACs) technology has been rapidly developed as a novel and selective medicinal strategy for the degradation of cellular proteins in cancer therapy. However, the applications of PROTACs as the heterobifunctional molecules are largely limited by high molecular weight, low bioavailability, poor permeability,...

Abstract Cancer is indisputably one of the major threats to mankind and hence the design of new approaches for the improvement of existing therapeutic strategies is always wanted. Herein, the design of a TME-responsive, DNA-based CDT nanoagent with dual Fenton reaction centers for targeted cancer therapy is reported. Self-assembly of DNA amphiphile...

Abstract Bionic tissues offer an exciting frontier in biomedical research by integrating biological cells with artificial electronics, such as sensors. One critical hurdle is the development of artificial electronics that can mechanically harmonize with biological tissues, ensuring a robust interface for effective strain transfer and local deformation...

Abstract The foreign body response (FBR) is an immune-mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that has consistently hampered their optimal utilization. Over the last decade, significant strides have...