Electrospun poly-l-lactic acid membranes with different alignments and diameters are prepared to investigate the effects of different surface morphologies on M2 macrophage polarization. Macrophages cultured on the electrospun membranes of the A600 group exhibit higher M2 macrophage polarization than the other three groups. Furthermore, electrospun...

A schematic depiction of the effects of various physical stimulations on the polarization of macrophage cells is presented. These effects dramatically alter when stimulation is applied in conjugation with micro/nanoplatforms. The synergistic role of micro/nanoplatforms and physical stimuli can be utilized to fabricate innovative immunomodulatory platforms...

A dinuclear Ru(II) complex (Ru2) is prepared for enhanced near-infrared light triggered synergetic photosensitization and photocatalytic anticancer therapy. Ru2 generates diverse reactive oxygen species and photocatalytically oxidized coenzyme NAD(P)H and multiple amino acids within cancer cells upon 700 nm LED light irradiation, leading to intracellular...

The demand for optical probes tailored to applications is ever rising for optogenetic research. Specifically, for applications such as the cochlea, transitioning from stiff glass fibers to flexible probes is required, especially for long-term use. Polydimethylsiloxane with its low Young's modulus can serve as material of choice. Its long-term usability...

Europium-doped strontium fluoride (SrF2:Eu) scintillating nanoparticles present tunable scintillation color and intensity by varying the nanoparticle size, efficient singlet oxygen production when conjugated to a photosensitizer (PS), and ability to kill cancer cells only when conjugated to the PS and exposed to X-Rays. Abstract Successful...

Abstract Image-guided tumor ablative therapies are mainstay cancer treatment options, but often require intra-procedural protective tissue displacement to reduce the risk of collateral damage to neighboring organs. Standard of care (SoC) strategies, such as hydrodissection (fluidic injection), are limited by rapid diffusion of fluid and poor retention...