Advanced Healthcare Materials
Abstract Early reconstruction of the vascular network is a prerequisite to the effective treatment of substantial bone defects. Traditional 3D printed tissue engineering scaffolds designed to repair large bone defects do not effectively regenerate the vascular network, and rely only on the porous structure within the scaffold for nutrient transfer...
Phototherapy promotes anti-tumor immunity by inducing immunogenic cell death, but the accompanying detrimental inflammatory responses also trigger immunosuppression, attenuating the efficacy of photoimmunotherapy. Herein, a nanodrug (CCP@DA) that coassembled from cell-membrane targeting chimeric peptide (CCP) and anti-inflammatory diclofenac (DA)...
An inflammation-responsive hydrogel incorporating Prussian blue nanoparticles is designed to reprogram the immune microenvironment for preserved bioavailability of loaded vascular endothelial growth factor, therefore augmenting the angiogenic efficacy to promote the healing process of diabetic wounds. Abstract Angiogenesis is a prominent...
A series of NIR-IIa emissive dibenzofluoran-based polymer dots are successfully synthesized. The properties of these molecules are fully studied and the bio-applications of these polymer dots including 3D vasculature imaging are also demonstrated. Abstract Emerging organic molecules with emissions in the second near-infrared (NIR-II) region...
The IR-808 and Nd3+ co-conjugated polymer NIR-II fluoroprobes with twisted intramolecular charge transfer state and Förster resonance energy transfer process are demonstrated for boosting NIR-II tail emission. The probes with rapid renal clearance are employed for angiography, middle cerebral artery occlusion mice imaging, and prognosis of acute kidney...
This work introduces the role of peptides in immune regulation of innate and adaptive immune cells, as well as immune checkpoints. Then this work introduces two strategies for delivering polypeptides: peptide self-assemblies, and peptide-functionalized nanocarriers. Finally, the challenges and prospects of peptides in tumor immunotherapy are summarized....