4,16-para-substituted [2.2]paracylophane with naphthalene (PCP⎼NAP), anthracene (PCP⎼ANTH), and tetraphenylethylene (PCP⎼TPE), as new through-space conjugated dimers, were prepared by the Suzuki–Miyaura cross-coupling reaction of 4,16-diboryl[2.2]paracyclophane and the corresponding bromo derivative using Pd(PPh3)4 as a catalyst and KOH as a base. The...

We report the construction of C5-indole unnatural amino acid derivatives via the diastereoselective Pd(II)-catalyzed prochiral β-C(sp3)-H arylation of racemic (DL), and enantiopure L- and D-carboxamides of amino acids with 5-iodoindoles. Independently, indole-based compounds and amino acid motifs are important small molecules in organic synthesis and...

A direct diastereoselective aldol reaction of cyclic or acyclic α-azido ketones with α-trifluoromethyl (CF3) pyruvate catalysed by DABCO is developed, which allowed the facile access of CF3-containing multifunctional organoazides with vicinal tetrasubstituted carbons in good to high yields and diastereoselectivities. Moreover, phenylethynyl trifluoro-...

This review aims to highlight the role that computational chemistry has played in advancing the supramolecular chemistry field. We demonstrated recent uses of computational methodologies to elucidate noncovalent interactions in various processes occurring in supramolecular systems. We also emphasized the contributions of these techniques to studying...

Sonogashira coupling on aryl bromides can be carried out under micellar conditions, in the absence of copper(I) catalyst, and under ambient atmosphere. Key of the success is the use of Kolliphor EL, a surfactant capable to form oxygen-free lipophilic domains in water. The method is applied toward the preparation of both (hetero)arylalkynes and luminescent...

The Daphniphyllum alkaloids represent a particularly diverse class of complex diterpene alkaloids, which are characterized by their enormous structural diversity. The daphnicyclidins, a subgroup of these alkaloids, stand out due to their unique pentafulvene structural motif. This review article gives an overview of the compounds that have been isolated...