P53 activation has enormous effects on developmental disorders such as microcephaly where its activation mediates apoptotic cell death in the brain. Here, we discuss routes of P53 activation and a new, non-apoptotic microcephaly pathogenic mechanism, entosis. We detail entotic mechanisms and the critical role of P53 activation in the process. ...

TRPV3, a warmth sensor, plays a role in maintaining skin homeostasis. The discovery of membrane protein TMEM79 modulation on TRPV3 in keratinocytes underscores their role in warmth sensation. Thus, comprehensive understanding of TRPV3 in physiology and pathology yields insight into skin function. Abstract Recent insights reveal the significant...

Both prokaryotes and eukaryotes possess multiple forms of dormant ribosomes under unfavorable conditions. Dormancy factors act as translation repressors by occupying functionally crucial ribosomal sites. Dormancy factors protect the ribosomes from the degradation pathways. Various signaling pathways such as ppGpp, mTOR, AMPK, and PKCε regulate the...

Useful variation in crop genes can be precisely identified using Agile Genetics, a framework for nesting a classical population within a much larger QTL-seq field study. Pangenomic graphs of founder parents assist each phase of the process, including iterative depth sequencing to maximize resolution at a reduced cost. Abstract Gene discovery...

BioEssays, EarlyView.

Motin family proteins (Motins) comprise Angiomotin (AMOT), AMOT-like protein 1 (AMOTL1), and AMOTL2. This review discusses the function of Motins, as upstream regulators or downstream effectors of the Hippo signaling pathway, in angiogenesis, tumorigenesis, and neurogenesis. Abstract The Motin family proteins (Motins) are a class of scaffolding...