Utilizing electrostatic layer-by-layer adsorption between polymers and arginase-2 (Arg-2) small interfering RNA (siRNA), the delivery system of poly(lactic-co-glycolic acid)/chitosan/siRNA/hyaluronan and surface decoration with kidney targeting peptide (KTP) achieves high renal selectivity through KTP-megalin and hyaluronan-CD44 interactions. Specific silencing...

A hydrogel (CHRgel) composed of arginine-rich peptide, cordycepin, and hyaluronic acid is reported that effectively promotes wound repair after neoadjuvant radiotherapy. This hydrogel can not only promote cell proliferation and adhesion by mimicking the extracellular matrix, but also release nitric oxide to promote neovascularization. Furthermore,...

It is proposed to modulate cartilage formation via the developed chondrocyte pericellular matrix (PCM) -like scaffolds for the first time, in which the S, M, and L-sized scaffolds of different pore size, depth, and stiffness are fabricated by femtosecond laser maskless optical projection lithography (FL-MOPL) of bovine serum albumin-glyceryl methacrylate...

Abstract For many clinically prevalent severe injuries, the inherent regenerative capacity of skeletal muscle remains inadequate. Skeletal muscle tissue engineering (SMTE) seeks to meet this clinical demand. With continuous progress in biomedicine and related technologies including micro/nanotechnology and 3D printing, numerous studies have uncovered...

This work details the development and thorough characterization of zinc-ferrite alloy and core–shell magnetic nanoparticles, offering new insights into the mechanisms of nanoparticle nucleation and growth that challenge classical theories. Additionally, this study successfully demonstrates the effectiveness of these nanoparticles for MRI-tracked magnetic...

Abstract Curcumin is a natural product found in the rhizome of Curcuma longa (L) and other Curcuma spp. As a lipophilic molecule, it has greater affinity for polar, non-polar, alkaline or extremely acidic organic solvents. Several studies indicate that curcumin has several benefits for human health, for example, against degenerative diseases, cancer...