Abstract In recent years, the demand for clinical bone grafting has increased. As a new solution for orthopedic implants, polyether ether ketone (PEEK, crystalline PAEK) has excellent comprehensive performance and has been practically applied in clinic. In this research, a noteworthy elevated scheme to enhance the performance of PEEK scaffolds was...

Abstract Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, and distinctive healing processes within the oral cavity. They have a common occurrence yet frequently inflict significant inconvenience and pain on patients, causing a serious decline...

Abstract The multifaceted biological defense system modulating complex immune responses against pathogens and foreign materials plays a critical role in tissue homeostasis and disease progression. Recently developed biomaterials that could specifically regulate immune responses, nanoparticles, graphene, and functional hydrogels have contributed to...

Utilizing electrostatic layer-by-layer adsorption between polymers and arginase-2 (Arg-2) small interfering RNA (siRNA), the delivery system of poly(lactic-co-glycolic acid)/chitosan/siRNA/hyaluronan and surface decoration with kidney targeting peptide (KTP) achieves high renal selectivity through KTP-megalin and hyaluronan-CD44 interactions. Specific silencing...

A hydrogel (CHRgel) composed of arginine-rich peptide, cordycepin, and hyaluronic acid is reported that effectively promotes wound repair after neoadjuvant radiotherapy. This hydrogel can not only promote cell proliferation and adhesion by mimicking the extracellular matrix, but also release nitric oxide to promote neovascularization. Furthermore,...

It is proposed to modulate cartilage formation via the developed chondrocyte pericellular matrix (PCM) -like scaffolds for the first time, in which the S, M, and L-sized scaffolds of different pore size, depth, and stiffness are fabricated by femtosecond laser maskless optical projection lithography (FL-MOPL) of bovine serum albumin-glyceryl methacrylate...